Arnaud scherpereel, hospital of the university of lille, france 16. This monograph provides the clinician with an uptodate summary of the substantial evidence in our understanding of pleural disease. Destination page number search scope search text search scope search text. Immune checkpoint inhibitors are promising new therapies for advanced cancers. Final results of a phase ii study initiate abstract id. Summary background there is no recommended therapy for malignant pleural mesothelioma that has progressed after firstline pemetrexed and platinumbased chemotherapy. Background the acute respiratory distress syndrome remains a common and poorly understood complication of a variety of insults. Stromal cell atypia was an independent prognostic factor for recurrence. Time is a doubleblind phase iibiii study comparing the combination of. Consensus statement from the college of pathologists, academy of medicine malaysia, the malaysian thoracic society, and the malaysian oncological society. Plateletendothelial cell adhesion molecule1directed. Endocan is a proteoglycan specifically secreted by endothelial cells. Development of precision medicine for malignant pleural mesothelioma mpm requires a deep knowledge of tumor heterogeneity.
Encouraging disease control rates observed w nivolumab alone or in combination with ipilimumab in refractory or relapsing malignant pleural mesotheli. The ifctgfpc0701 maps phase iii trial highlighted significant improvement in overall survival from adding bevacizumab to the standard firstline chemotherapy regimen cisplatin plus pemetrexed pc, in advanced malignant pleural mesothelioma mpm. The standard frontline treatment, cisplatin plus pemetrexed chemotherapy, has only short and insufficient efficacy, and no validated treatment beyond. Emergency casebook haemothorax after pigtail catheter removal in a patient with primary spontaneous pneumothorax demosthenes makris, medi hatthabi, arnaud scherpereel, jeanjaques lafitte, charleshugo. Endocan expression and relationship with survival in human. Emergency casebook haemothorax after pigtail catheter.
Cameron 11, tobias peikert 12, carly campbell , inbal sapir , alice mcdonald , coreen oei , alicia clawson , maria roche , dean a. In this study, we characterized pecamdirected targeting to the lung and heart after local versus systemic intravascular administration in a large animal model, pigs. Therapeutic molecules conjugated with antibodies to the plateletendothelial cell adhesion molecule1 pecam1 accumulate in the pulmonary endothelium after i. Three cases of pembrolizumabinduced pneumonitis are described, two being consistent with. Arnaud scherpereel the lancet, european respiratory. The documents contained in this web site are presented for information purposes only. Zauderer1, peter szlosarek2, sylvestre le moulec3, sanjay popat4, paul taylor5, david planchard6, arnaud scherpereel7, thierry jahan8, marianna koczywas9, martin forster 10, robert b. Differences in response, 95% hauckanderson cis, and a twosided cochranmantelhaenszel 2 test strati. Novel therapies for malignant pleural mesothelioma the. Supplementary appendix this appendix has been provided by the authors to give readers additional information about their work. Pembrolizumabinduced pneumonitis european respiratory. Overexpression of endocan induces tumor formation cancer. Patients with malignant pleural mesothelioma have poor outcomes with suboptimal therapeutic options and.
We evaluated the expression of endocan, a soluble lung and kidneyselective endothelial cellspecific dermatan sulfate proteoglycan, in nonsmall cell lung tumors compared with normal lung and studied the significance of high levels of circulating endocan in patients with nonsmall cell lung cancer. Recent findings to date, global gene profiling studies have failed to find a molecule that reliably captures all subtypes of mesothelioma, and differentiates it from benign pathologies and metastatic carcinomas. It covers key aspects relevant to clinicians, including mechanisms, pathophysiology, epidemiology, diagnostics, relevant experimental models and interventions. Histologic and molecular classifications and histo. On this basis, we designed a randomized, phase ii trial to investigate whether defactinib as maintenance therapy after standard firstline chemotherapy could improve progressionfree survival pfs in patients with malignant. Through its glycan domains, endocan binds to hepatocyte growth factor and increases its mitogenic activity. Here, we show that human embryonic kidney 293 cells, which have been genetically engineered to overexpress endocan, form tumors when injected s. Vol 8, no 3 june 2019 translational lung cancer research. Reliable information about the coronavirus covid19 is available from the world health organization current situation, international travel. Mesothelioma avastin plus pemetrexedcisplatin study. Malignant pleural mesothelioma mpm is a rare and aggressive cancer related to asbestos exposure. Tg4010 immunotherapy combined with firstline therapy in.
Correspondence and requests for reprints should be addressed to arnaud. Can studies on early palliative care be harmful to patient. The discovery of soluble biomarkers with diagnosticprognostic andor therapeutic properties would improve therapeutic care of mpm patients. In particular, antibodies against programmed cell death 1 pd1, such as nivolumab and pembrolizumab, increase antitumour t cell responses by blocking the interaction between pd1 on t cells and its ligand pdl1 on cancer cells 1. Maintenance defactinib versus placebo after firstline. The leading interdisciplinary journal reporting on the clinical, educational, legal, and ethical aspects of palliative care for patients in end of life or with intractable pain, focusing on improving quality of life. Systemic management of 2019 malignant pleural mesothelioma. Nivolumab monotherapy or nivolumab plus ipilimumab, for.
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. Arnaud scherpereel chu lille, pneumology and thoracic oncology, lille, france. Enhanced tcell responses resulting from checkpoint inhibition can lead to. Ventilation with high concentrations of inspired oxygen may further damage already compromised lungs. All patients relapse despite initial chemotherapy, more than 50% of them within six months after stopping treatment. Oclcs webjunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus. Soluble mesothelinrelated peptides in the diagnosis of. Regarding the risk factors for pembrolizumabinduced pneumonitis, little is known, but smoking, prior treatment, lung cancer, prior thoracic radiotherapy, and prior lung disease were suggested to. Brainderived neurotrophic factor, a new soluble biomarker. Soluble mesothelinrelated peptide smrp, osteopontin and megakaryocyte potentiating factor have been assessed as markers. Mesothelioma avastin plus pemetrexedcisplatin study maps the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Ipilimumab and nivolumab in the treatment of malignant pleural mesothelioma.
Pembrolizumabinduced pneumonitis vincent leroy, carole templier, jeanbaptiste faivre, arnaud scherpereel, clement fournier, laurent mortier, lidwine wemeaustervinou erj open research apr 2017, 3 2 000812016. Tg4010 immunotherapy product is a poxvirus mva coding for muc1 tumorassociated antigen and interleukin2. Chicago malignant pleural mesothelioma or mpm is a rare cancer, but its incidence has been rising. Genetic alterations of malignant pleural mesothelioma. Numerous and frequentlyupdated resource results are available from this search. Antitumor immunotherapy in malignant pleural mesothelioma. Nivolumab monotherapy or nivolumab plus ipilimumab, for unresectable malignant pleural mesothelioma mpm patients maps2 the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Patients with malignant pleural mesothelioma have poor outcomes with suboptimal therapeutic options and currently no treatment is curative. By scavenging extracellular actin and modulating the effects of lysophosphatidic acid, plasma gelsolin could serve a critical protective role against oxidant. A new assay for the detection of mesothelioma in blood samples georg johnen1, irina raiko1, ingrid sander 1, daniel g.
A case of fatal acute liver failure in a 68 year old. She received daily injections of fondaparinux because of a recent pulmonary embolism. Journal of thoracic oncology vol, issue 9, pages a1. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. We present the results of healthrelated quality of life hrqol, a secondary endpoint of maps. Second or third line nivolumab vs nivolumab plus ipilimumab in mpm patients maps2 esoesmo eebr masterclass 2019. Esoesmo presented by arnaud scherpereel at 2017 asco annual meeting eebr masterclass 2019. Endocan and vascular endothelial growth factor mrna. Arnaud scherpereel, frederic wallyn, steven m albelda, camille munck malignant pleural mesothelioma is a rare cancer that is typically associated with exposure to asbestos. Pneumologie developpement 2004 and from respir association lille, 2006 a.
Ensure your research is discoverable on semantic scholar. Listing a study does not mean it has been evaluated by the u. Kinetics of soluble mesothelin in patients with malignant. Currently, soluble biomarkers described present weaknesses preventing their use in clinic. Research article open access defect in recruiting effector. A 68 year old female with a history of levothyroxinesubstituted hypothyroidism was diagnosed with metastatic lung adenocarcinoma. Purpose inhibition of focal adhesion kinase has been shown to selectively kill mesothelioma cells that express low levels of moesinezrinradixinlike protein merlin. Malignant pleural mesothelioma is a rare cancer that is typically associated with exposure to asbestos. Encouraging disease control rates observed with nivolumab.
She was treated with 3 courses of a platinumbased chemotherapy as firstline treatment and docetaxel as secondline treatment. Departments of pulmonary and thoracic oncology, thoracic surgery, and pathology. Pr arnaud scherpereel medecin pneumologie hopital calmette, chru. Surgical approach and tumor border were independent prognostic factors for rfs in the high. Specialistes du mesotheliome en france amianteetmensonge. This cancer is usually associated with asbestos exposure, and patients have a median life expectancy of only 15 months. Semantic scholar profile for arnaud scherpereel, with 5 highly influential citations and 10 scientific research papers.
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